Let's face it, you're gunna reload. You don't die in the game. There's all these causal paths where something blew you up - but...not really, that got pruned at the press of a quick load key.
So what if the losing condition was that the monsters manage to escape? You can't die - get your health knocked down to a certain level and the monsters freak out and leave through various unfollowable escape hatches.
"But that's frustrating - I hate letting any monsters get away!"
Exactly. That's why this isn't going to sell on you, but to have some kind of literary merit in a game, it has to screw with what you prefer to some degree.